What are your "must-read" books on aging?

Aging Books - karl pfleger’s books (more conventional/mainstream than my list). I’m including a lot of books that aren’t core to aging, but which someone who wants to build first principles should learn

One tip: search carboxymethyllysine - Google Search on google books
or 4-Hydroxynonenal - Google Search
or all the individual modifications to How does DNA get damaged by reactive oxygen species? - Quora

https://www.amazon.com/Future-Aging-Pathways-Human-Extension-ebook/dp/B00A9YFU9S/ref=sr_1_fkmr1_1?dchild=1&keywords=greg+fahy+aging&qid=1623571410&sr=8-1-fkmr1 - most important book of them all

replacing aging (jean hebert)

Ending Aging: The Rejuvenation Breakthroughs That Could Reverse Human Aging in Our Lifetime

Protein Actions: Principles and Modeling

Aging, oxidative stress, and dietary antioxidants (Google Books )

ANYTHING BY [Victor R. Preedy]

Tocotrienols: Vitamin E Beyond Tocopherols, Second Edition

Aging of the Genome: The Dual Role of DNA in Life and Death

Evolutionary aging

Introduction to Proteins: Structure, Function, and Motion, Second Edition (this is as core as Alberts is - protein homeostasis is upstream of basically anything in aging)

Uri Alon systems biology
Phillips Physical biology of the cell

I haven’t seen anyone successfully apply stat mech for aging (aka it hasn’t been helpful for a lot of progress in the past, but radical approaches from an appropriate genius may be one of the best ways of creating “jumpy” progress in the field). For stat mech, try https://twitter.com/stevenstrogatz/status/1396795635433623552

I would also suggest [not for everyone] biophysics books (though few of them are, like, super-applicable to aging), alberts molecular biology of a cell, a medicinal chemistry textbook, a toxicology textbook, physical organic chemistry (eg https://www.amazon.com/Modern-Physical-Organic-Chemistry-Anslyn/dp/1891389319/ref=sr_1_3?dchild=1&keywords=physical+organic+chemistry&qid=1631649847&sr=8-3 ), and bionanotechnology textbooks

a toxicology book! (eg patty’s toxicology) also environmental health. histology/neurohistology also impt! There is SO MUCH RESEARCH ON TOXICOLOGY THAT GIVES YOU SO MUCH BOTTOM-UP INTUITION ON HOW TO MEASURE/ASSAY DAMAGE.

Also for those on the bioengineering front [important but not my area] - try bioengineering/nanotechnology/drug delivery textbooks

STANDARD biochemistry textbooks like Voet, or https://www.amazon.com/Essentials-Glycobiology-Third-Ajit-Varki/dp/1621821323/ref=sr_1_1?dchild=1&keywords=glycobiology&qid=1628571443&s=books&sr=1-1 . Get up to date with your proteins, nucleic acids, lipids (knowing ALL of them is relevant, though you needn’t be an expert in it all)

the energetics of computing in life and machines

some engineering textbooks (eg use finite element modeling to model metabolic flux in sysbio )

Above-average relevance, also easy to read

  • The Next 500 Years: Engineering Life to Reach New Worlds (esp first few chapters)
  • Regenesis (George Church)
  • Leroy Hood’s biography

Engineering

Those who make aging/science beautiful to understand (or more clearly define the primitives)

ON THE SCIENTIFIC PROCESS (and avoiding burnout in the process/not getting discouraged)

Nutrition

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+1 for Uri Alon. He has an interesting model for senescent cell “circuits” that models the Gompertzian hazard ratio. I wonder how much headway one can make with these theoretical physics approaches. Perhaps we are beyond theory now, just need to do the applied translation.

i saw laura recommend Introducing Epigenetics: A Graphic Guide once

super-specialized but impt for developing models of specialization (also great for example learners): Tocotrienols - vitamin E beyond tocopherols-CRC Press (2013)

Autophagy in mammalian systems

The extraordinary biology of the naked mole rat

A good book on multivariate statistics (you can first start out with Regression Analysis - An Intuitive guide)

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Bharath Deep Learning for the Life Sciences

Shameless plug! https://www.amazon.com/Finding-Fountain-Government-Potential-Longevity-ebook/dp/B08L8T2N8Y

https://www.amazon.com/Experimental-Man-Reveals-Future-Health-ebook/dp/B00DNL166A (experimental man)

https://cshlpress.com/default.tpl?action=full&--eqskudatarq=1282

i think many of the “techniques books” (harder to find esp for someone socialized among SPARC crowds) are probably much more useful for the average person in aging than a stat mech textbook so I need to be better at finding them

ALSO books on https://www.amazon.com/s?k=medicinal+plants&ref=nb_sb_noss (medicinal plants) and Pharmacognosy - Wikipedia and marine drugs (also DRUG DISCOVERY and MEDICINAL CHEMISTRY BOOKS)

Ira Pastor called this the bible: Principles of Regenerative Biology | ScienceDirect

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b/c really, neuronal structure is all that matters

also morgan levine’s latest book!

SERGEY YOUNG - Growing Young → has the breadth and technophilic bent that others don’t have (you can see some stuff from longevity.technology referenced here), but somewhat weak on details (esp on rapamycin), and is naive in believing that people still take Ray Kurzweil’s predictions seriously.

Prolongevity II : an updated report on the scientific prospects for adding good years to life : Rosenfeld, Albert : Free Download, Borrow, and Streaming : Internet Archive prolongevity is an early look into the field!!

https://www.amazon.com/Statistical-Physics-Biomolecules-Daniel-Zuckerman-ebook/dp/B005H6YEBI/?encoding=UTF8&pd_rd_w=3vnlC&pf_rd_p=8b894231-4b84-44da-9446-c27cf0e8abc2&pf_rd_r=C4TYJB9PBM290F0VW44F&pd_rd_r=e12066a4-89a9-445a-b23c-68cfc97cc34c&pd_rd_wg=iSBca&ref=pd_gw_ci_mcx_mr_hp_d

https://www.amazon.com/Biophysics-Introduction-Rodney-Cotterill-ebook/dp/B000VHVMDG/?encoding=UTF8&pd_rd_w=3vnlC&pf_rd_p=8b894231-4b84-44da-9446-c27cf0e8abc2&pf_rd_r=C4TYJB9PBM290F0VW44F&pd_rd_r=e12066a4-89a9-445a-b23c-68cfc97cc34c&pd_rd_wg=iSBca&ref=pd_gw_ci_mcx_mr_hp_d

https://drorlab.stanford.edu/

^not directly aging, related, but learn the hardest things first and then apply to biology if you can

Physics And Biology: From Molecules To Life , Jean-francois Allemand, Pierre Desbiolles - Amazon.com => underrated, focuses attention on impt biomarkers not often seen in other texts