What are your "must-read" books on aging?

One tip: search carboxymethyllysine - Google Search on google books
or 4-Hydroxynonenal - Google Search
or all the individual modifications to How does DNA get damaged by reactive oxygen species? - Quora

https://www.amazon.com/Future-Aging-Pathways-Human-Extension-ebook/dp/B00A9YFU9S/ref=sr_1_fkmr1_1?dchild=1&keywords=greg+fahy+aging&qid=1623571410&sr=8-1-fkmr1 - most important book of them all

replacing aging (jean hebert)

Ending Aging: The Rejuvenation Breakthroughs That Could Reverse Human Aging in Our Lifetime

Protein Actions: Principles and Modeling

Aging of the Genome: The Dual Role of DNA in Life and Death

Introduction to Proteins: Structure, Function, and Motion, Second Edition (this is as core as Alberts is - protein homeostasis is upstream of basically anything in aging)

Uri Alon systems biology
Phillips Physical biology of the cell

I haven’t seen anyone successfully apply stat mech for aging (aka it hasn’t been helpful for a lot of progress in the past, but radical approaches from an appropriate genius may be one of the best ways of creating “jumpy” progress in the field). For stat mech, try https://twitter.com/stevenstrogatz/status/1396795635433623552

I would also suggest [not for everyone] biophysics books (though few of them are, like, super-applicable to aging), alberts molecular biology of a cell, a medicinal chemistry textbook, a toxicology textbook, physical organic chemistry, and bionanotechnology textbooks

a toxicology book! histology/neurohistology also impt!

Also for those on the bioengineering front [important but not my area] - try bioengineering/nanotechnology/drug delivery textbooks

the energetics of computing in life and machines

Above-average relevance, also easy to read

  • The Next 500 Years: Engineering Life to Reach New Worlds (esp first few chapters)
  • Regenesis (George Church)
  • Leroy Hood’s biography


Those who make aging/science beautiful to understand (or more clearly define the primitives)

ON THE SCIENTIFIC PROCESS (and avoiding burnout in the process/not getting discouraged)


+1 for Uri Alon. He has an interesting model for senescent cell “circuits” that models the Gompertzian hazard ratio. I wonder how much headway one can make with these theoretical physics approaches. Perhaps we are beyond theory now, just need to do the applied translation.

i saw laura recommend Introducing Epigenetics: A Graphic Guide once

super-specialized but impt for developing models of specialization (also great for example learners): Tocotrienols - vitamin E beyond tocopherols-CRC Press (2013)

Autophagy in mammalian systems

A good book on multivariate statistics (you can first start out with Regression Analysis - An Intuitive guide)

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Bharath Deep Learning for the Life Sciences

Shameless plug! https://www.amazon.com/Finding-Fountain-Government-Potential-Longevity-ebook/dp/B08L8T2N8Y

David Ewing Duncan book


i think many of the “techniques books” (harder to find esp for someone socialized among SPARC crowds) are probably much more useful for the average person in aging than a stat mech textbook so I need to be better at finding them