Longevity and Evolution (Aging Issues, Health and Financial Alternatives)
by Gustavo Barja | Jan 1, 2011
markov.bio
EVERYTHING Nick Lane.
Elliot Hershberg, Niko McCarthy (ask him for recs, though his taste is not the same as mine)
Bionanotechnology by David S. Goodsell [AND his other books]
Aging Books - karl pfleger’s books (more conventional/mainstream than my list). I’m including a lot of books that aren’t core to aging, but which someone who wants to build first principles should learn
One tip: search carboxymethyllysine - Google Search on google books
or 4-Hydroxynonenal - Google Search
or all the individual modifications to https://www.quora.com/How-does-DNA-get-damaged-by-reactive-oxygen-species
Amazon.com - most important book of them all
Cracking the Stem Cell Code, way more readable/presents a map than any of the exosomes papers I tried [and failed] to read). Orthogonal to all the other books.
replacing aging (jean hebert)
Ending Aging: The Rejuvenation Breakthroughs That Could Reverse Human Aging in Our Lifetime
Protein Actions: Principles and Modeling
Aging, oxidative stress, and dietary antioxidants (Google Books )
ANYTHING BY [Victor R. Preedy]
Tocotrienols: Vitamin E Beyond Tocopherols, Second Edition
Aging of the Genome: The Dual Role of DNA in Life and Death
Evolutionary aging
Introduction to Proteins: Structure, Function, and Motion, Second Edition (this is as core as Alberts is - protein homeostasis is upstream of basically anything in aging)
Uri Alon systems biology
Phillips Physical biology of the cell
I haven’t seen anyone successfully apply stat mech for aging (aka it hasn’t been helpful for a lot of progress in the past, but radical approaches from an appropriate genius may be one of the best ways of creating “jumpy” progress in the field). For stat mech, try https://twitter.com/stevenstrogatz/status/1396795635433623552
I would also suggest [not for everyone] biophysics books (though few of them are, like, super-applicable to aging), alberts molecular biology of a cell, a medicinal chemistry textbook, a toxicology textbook, physical organic chemistry (eg Amazon.com ), and bionanotechnology textbooks
a toxicology book! (eg patty’s toxicology) also environmental health. histology/neurohistology also impt! There is SO MUCH RESEARCH ON TOXICOLOGY THAT GIVES YOU SO MUCH BOTTOM-UP INTUITION ON HOW TO MEASURE/ASSAY DAMAGE.
Also for those on the bioengineering front [important but not my area] - try bioengineering/nanotechnology/drug delivery textbooks
STANDARD biochemistry textbooks like Voet, or Amazon.com . Get up to date with your proteins, nucleic acids, lipids (knowing ALL of them is relevant, though you needn’t be an expert in it all)
- LAST CHAPTER of https://www.amazon.com/Beginning-Infinity-Explanations-Transform-World/dp/0143121359
the energetics of computing in life and machines
some engineering textbooks (eg use finite element modeling to model metabolic flux in sysbio )
Above-average relevance, also easy to read
- The Next 500 Years: Engineering Life to Reach New Worlds (esp first few chapters)
- Regenesis (George Church)
- Leroy Hood’s biography
Engineering
Those who make aging/science beautiful to understand (or more clearly define the primitives)
- Roald Hoffman for chemistry
- Reactions: The Private Life of Atoms
- Nick Lane books on mitochondria
- David S. Goodsell
ON THE SCIENTIFIC PROCESS (and avoiding burnout in the process/not getting discouraged)
- Ricon recommended https://www.amazon.com/Discovering-Inventing-Frontiers-Scientific-Knowledge/dp/0735100071/ref=sr_1_1?dchild=1&qid=1620384447&refinements=p_27%3ARobert+Scott+Root-Bernstein&s=books&sr=1-1
- Avoid Boring People (James Watson). So much time is wasted on boringness, and it really burns people and prevents people from being at their best (and drains a lot of the smartest people out of biology). We can do better)
- https://twitter.com/hashtag/theeighthdayofcreation?src=hashtag_click
- Letters to a Young Scientist (EO Wilson)
- 101 Theory Drive: A Neuroscientist’s Quest for Memory
- The Structure of Scientific Revolutions
- Dean Simonton - Amazon.com , Amazon.com, Amazon.com
- Zero to One (Thiel)
Nutrition
- The CR Way: Using the Secrets of Calorie Restriction for a Longer, Healthier Life
- How Not to Die: Discover the Foods Scientifically Proven to Prevent and Reverse Disease (his YouTube videos are great)
- The Mindspan Diet: Reduce Alzheimer’s Risk, Minimize Memory Loss, and Keep Your Brain Young (IRON is bad)
- The Longevity Diet: The Only Proven Way to Slow the Aging Process and Maintain Peak Vitality–Through Calorie Restrictio
- Ray Kurzweil’s Fantastic Voyage