The air pollution thread

https://www.pnas.org/content/117/25/13856

see caleb finch too. and the mexico city pollution study on dogs near roadways and all the plaque they developed

Wear N95/N99 masks when on the subways or near major roadways. Thomas Talheim has a blog (smartairfilters.com) showing that even low-levels of PM1/PM2.5 found in American cities (even NYC/Chicago) are enough to increase inflammation/irritability levels. Do not live within 300 years of a major arterial roadway (esp one populated by trucks or diesel-emitting vehicles). The best air quality is found in US/Canada/ocean-touching areas of Europe. Most of the pollution from automobiles may be from cars causing friction against the asphalt (this is where all electric-powered subway pollution comes from!!), which means that some protection against PM2.5 is necessary even when we transition to all-electric (the amount of PM2.5 emitted here scales nonlinearly with the speed by which the car touches asphalt).

Stay away from laser printers (tho my pollution monitors have never picked up signal when they print). Or at least wear a N95 when next to one (though it’s not clear if they will filter out EVERYTHING - thoams talhelm says they PROBABLY filter out even the nanoparticles but one cannot be too sure). I totally remember feeling intense regret when forgetting to wear one when I randomly bolted from a group restaurant in Kotor, MNE and kept on having to face diesel fumes (luckily the PM2.5 never went above 15 during the isolated moments when a truck passed by me, but it still HURT)

Blast and sqair have best air purifiers

for monitors - https://smartairfilters.com/en/blog/best-pm2-5-air-quality-monitors-in-2021/

If you want to go to a unique extreme, semiconductor fabs have the most heavily filtered air ever - Semiconductor | Camfil

[how many particles per day does one breath in from PM2.5 of 7.5 (keep in mind that AVERAGE LIFETIME ingestion of PM2.5 is more like 10-15 integrated across a zillenial’s lifetime), and how does that compare to average daily intake of microplastics?]


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David FurmanDavid Furman • 1st • 1stAcademic entrepreneur, using Computational Immunology to extend healthspan and longevityAcademic entrepreneur, using Computational Immunology to extend healthspan and longevity4d • 4 days ago

HOW DO WE TARGET INFLAMMATION TO SLOW DOWN BIOLOGICAL AGING?

The list of long, but a few examples listed below. Healthy Longevity is Possible

Based on more than 10 years of research, I’ve concluded three pillars to follow:

1- Protect
2- Challenge
3- Repair

The first pillar PROTECT involves the so called ‘exposome’. Examples below and in the images more information regarding CHALLENGE and REPAIR.

Air quality, example: pollutants in the air we breath such as PM2.5 and PM10 increase inflammaging proteins such as Eotaxin-1 a key protein that accelerates BRAIN AGING. Formaldehyde, found in the air of houses with new furniture for example, increases CXCL9 levels a protein that accelerates CARDIOVASCULAR AGING.

Grains, dairy products, legumes; all highly inflammatory with known pro-aging pathways!

Processed foods, example: polysorbate-80, carboxymethyl cellulose found almost in every processed food, cause massive destruction of our MICROBIOME (dysbiosis) reducing the mucin layer in our gut with results in the leakage of luminal antigens into our peripheral circulation causing upregulation of many inflammaging cytokines including the NFkB system. By disrupting out microbiome we also eliminate important anti-inflammatory metabolites such as short chain fatty acids, produced by our gut microbiome.

Plastics, example: these are most everywhere and act as endocrine disruptors since they have similar chemical structure as sex hormones (increase risk of CANCER in women and feminize exposed men (shrinkage of testis size and enlargement of breast tissue! These also cause direct upregulation of inflammaging pathways NFkB, MyD88 and NLRP3 in terms of proteins and gene expression.

Commonly used drugs, example: Acetaminophen reduces levels of TRAIL an Inflammatory Age protein (higher is better here) involved in clearance of senescence cells.