- The amount of lysosomal lipofuscin was significantly higher (6-fold) in cell bodies of aged neurons (28
- Moreover, we observed a drastic reduction in doublecortin expression, a neuronal precursor marker, from 14 to 28 DIV, as described previously
- John Wentworth and CANanonymity@fightaging also have good lists
I really mitoSENS solves ATP loss with aging due to oxidized redox cell environment.
From 0 tp 40 years old, the plasma redox is roughly -140 mV, then +7 mv/decade rise, until at 70-85 years old, it is -110 mV.
At that high mV current the cell is a continuous oxidative stress state. It is why humans end up dying at 122 years old MLSP.
Lipofuscin granules, which range between 1 and 3 μm in diameter, appear as brownish particles in neuronal cytoplasm and are probably indigestible residues of lysosomes materials
33% of human proteins have four consecutive positive charged amino acids.