List of aging-relevant bionumbers

  • The amount of lysosomal lipofuscin was significantly higher (6-fold) in cell bodies of aged neurons (28
  • Moreover, we observed a drastic reduction in doublecortin expression, a neuronal precursor marker, from 14 to 28 DIV, as described previously
  • John Wentworth and CANanonymity@fightaging also have good lists

I really mitoSENS solves ATP loss with aging due to oxidized redox cell environment.

From 0 tp 40 years old, the plasma redox is roughly -140 mV, then +7 mv/decade rise, until at 70-85 years old, it is -110 mV.
At that high mV current the cell is a continuous oxidative stress state. It is why humans end up dying at 122 years old MLSP.

Lipofuscin granules, which range between 1 and 3 μm in diameter, appear as brownish particles in neuronal cytoplasm and are probably indigestible residues of lysosomes materials

33% of human proteins have four consecutive positive charged amino acids.

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The protein concentration in our cells is ~ 200 mg / ml.

bionumbers claims 9%-22% of cellular protein is ribosomal, so multiplying through that would be ~5-10% of energy

That is to say, despite the thousands of noncovalent interactions existing in the structures of folded proteins [27], they are merely 5 to 15 kcal/mol more stable than the unfolded chain [28–30]. For comparison, the dissociation of a single covalent bond requires ~65 to 175 kcal/mol [3]. The low stability of proteins can be explained in two ways. First, even in the lower stability limit (−5 kcal/mol) the folded state is over 99.9% occupied

timescales of motions in proteins

The pK a values of cysteine residues are of critical importance in redox-regulated processes. At physiological pH, the pK a values of protein cysteine thiols vary from 8.2 to 9.9 for solvent-accessible cysteines and therefore have low deprotonation ability [47]. Cysteine thiols within a basic three-dimensional environment (low pK a) are more susceptible to deprotonation and oxidation to sulfenic acid in the presence of ROS

Cytoplasmic and nuclear NAD+/NADH ratios are typically maintained between 60 and 700 in eukaryotes depending on cell type, while the mitochondrial ratio is much lower, around 7–8 (Veech et al., 1972, Williamson et al., 1967, Zhang et al., 2002). Additionally, mitochondria contain a large proportion of cellular NAD+, with estimates ranging from 40%–70% of the total cellular NAD+ pool (Alano et al., 2007, Di Lisa et al., 2001, Tischler et al., 1977).