Canonical aging papers (more worth reading than others)

Especially for new people (lots of people are still confused as to what’s important or what to focus attention on - if we figure out how to get people to focus their attention better, it really drastically increases our ability to solve the coordination problem). There are more papers than time available to read, so choose the ones that summarize the most information with the least filler possible (review papers are often best for this, and are often better than the seminal papers in the field [which often lack insight as to physical mechanism]). The best papers take a big-picture or comparative view (you can use scoping to force a big-picture view even with individual post-translational modifications on specific proteins)

Targeting resilience may enable human lifespan extension (I find the one mentioned here interesting enough to want to understand more - though it uses a not-fully-grounded model)

Also, Denis Odinokov posts A LOT of good papers and has far higher breadth than most aging researchers

MY FAVORITE ITEMS ON PUBMED (530 items) - Favorites - My NCBI Collection

Comparative Biology of Aging

  • The Long Life of Birds: The Rat-Pigeon Comparison Revisited

Lipid/membrane Repair

Translation/Transcription (as naked mole rats show, many protein aggregates form DURING the process of translation/transcription b/c it is when they are in their most vulnerable state, so fix the upstream process)


Biophysical Profiling

** Metabolomics **

  • Undulating changes in human plasma proteome across lifespan are linked to disease


  • Lopes et al. - 2020 - Gene size matters What determines gene length in the human genome
  • Title: Aging is associated with a systemic length-driven transcriptome imbalance
  • Bartas et al. - 2020 - The changes in the p53 protein across the animal kingdom pointing to its involvement in longevity
  • Mariadassou, Pellay - 2014 - Identification of amino acids in mitochondrially encoded proteins that correlate with lifespan
  • Studer, Robinson-Rechavi - 2009 - How confident can we be that orthologs are similar, but paralogs differ
  • Peto’s Paradox: evolution’s prescription for cancer prevention
  • Relaxed Selection Limits Lifespan by Increasing Mutation Load - PubMed


Protein/Lipid/Nucleic Acid Aggregation

Neurons (really the most important celltype, so maintain them well)


Long-Lived Structural Proteins

Theoretical Proteostasis

Small Molecules
Terpenoids as Potential Geroprotectors.


*** Th**e landscape of the alternatively spliced transcriptome remains stable during aging across different species and tissues

Structural Biology


An Overview of the Role of Lipofuscin in Age-Related Neurodegeneration.

Surprisingly Crazy Interventions
(look at chimeric studies, look at T-cell and mitochondrial transfer)


Tangential Insight-Dense Papers

** Chemical-level **

  • Chemical biology of mutagenesis and DNA repair: cellular responses to DNA alkylation
  • Unraveling Oxidative Stress Resistance: Molecular Properties Govern Proteome Vulnerability
    Glucose, glycation and aging

Structural Biology

  • The nuclear pore complex – structure and function at a glance

Brain Aging

Cell Death/Hypoxia

I would also look up reperfusion injury and H2S suspended animation - has LOTS of relevance

** General Neuro**


CLASSIFY LATER (unsure of importance)

Wang-michelitsch, Michelitsch - 2015 - Potential of longevity hidden in structural complexity
Recent progress in the biology and physiology of sirtuins.


  • Neuronal intrinsic mechanisms of axon regeneration.

Neuronal intrinsic mechanisms of axon regeneration.

Alternative biochemistry

  • Did Evolution Select a Nonrandom “Alphabet” of Amino Acids?
  • Adding new chemistries to the genetic code.

The emerging role of alternative splicing in senescence and aging.

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Also you will have to google “aging + EVERY biological compartment”


aging + golgi
aging+ endoplasmic reticulum
aging + spliceosome
aging + cytoskeleton
aging + nuclear membrane
aging + vimetin
aging + nuclear pore protein
aging + early endosome
aging + late endosome
aging + epitranscriptome
aging + chromatin
aging + histones
aging + nucleosome

[there will almost certainly be a review paper on this]

classify later

pulsed mitochondrial ros

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also spatial-omics!

[a lot of next-gen stuff which will be helpful for seeing mechanistic effects of interventions!!]

chemical biology/nonenzymatic modifications - Discovering the landscape of protein modifications

SENS papers are well above-average relevance but I de-emphasize them here to reduce redundancy/increase uniqueness of my content