URLs on my deep dives into both p53 and proteasomes last night

[AlexKChen]

https://www.cell.com/fulltext/S0092-8674(11)01007-5
Beclin1 Controls the Levels of p53 by Regulating the Deubiquitination Activity of USP10 and USP13: Cell

The most promising supplements/small molecules for longevity

lyosomal acidifiers (only in old ppl) - https://pubs.acs.org/doi/10.1021/acschemneuro.1c00804 valproic acid in c elegans? Valproic acid - is it pro-longevity or anti-longevity? (it helps open up chromatin, which might make it more damage-prone) - Rapamycin News bromodomain inhibitors? => i would not expect huge effect sizes in these, but some of these can be targeted well…

The most promising supplements/small molecules for longevity - akc-important-threads - LongevityBase Forum

Beclin 1, an autophagy-related gene, augments apoptosis in U87 glioblastoma...

Beclin 1, an autophagy-related gene, augments apoptosis in U87 glioblastoma cells

Progress and challenges in understanding the regulation and function of p53...

Progress and challenges in understanding the regulation and function of p53 dynamics | Biochemical Society Transactions | Portland Press
https://aip.scitation.org/doi/10.1063/5.0030558
Landscape and flux quantify the stochastic transition dynamics for p53 cell fate decision: The Journal of Chemical Physics: Vol 154, No 2
https://www.nature.com/articles/cdd201526
DRAM-3 modulates autophagy and promotes cell survival in the absence of glucose | Cell Death & Differentiation

DRAM links autophagy to p53 and programmed cell death - PubMed

DRAM links autophagy to p53 and programmed cell death - PubMed
https://www.cell.com/fulltext/S0092-8674(06)00759-8
DRAM, a p53-Induced Modulator of Autophagy, Is Critical for Apoptosis: Cell

PUMA, a potent killer with or without p53

PUMA, a potent killer with or without p53 - PMC
https://www.google.com/search?q=transcription+factors+CHOP&client=firefox-b-1-d&sxsrf=ALiCzsa1L-XuAoOmzFjSN8y9gbuSxLVDVw:1652683578832&tbm=isch&source=iu&ictx=1&vet=1&fir=aCeQWDhBZGSlWM%2CPFc-tdpFOCzhiM%2C_%3Blf-MXT8UZxVAoM%2CPFc-tdpFOCzhiM%2C_&usg=AI4_-kSsYGJYGQhGG-PUZ0YVG3bSIyt11w&sa=X&ved=2ahUKEwitu5GNtuP3AhWglIkEHbQHBuAQ_h16BAgsEAE&biw=1352&bih=1079&dpr=0.9#imgrc=B8oH_RREDWAYEM
transcription factors CHOP - Google Search

The C/EBP Homologous Protein (CHOP) Transcription Factor Functions in...

Frontiers | The C/EBP Homologous Protein (CHOP) Transcription Factor Functions in Endoplasmic Reticulum Stress-Induced Apoptosis and Microbial Infection | Immunology

fimmu-09-03083-g001.jpg (JPEG Image, 772 × 479 pixels)

ERN1

ERN1 - Wikipedia
https://www.sciencedirect.com/topics/medicine-and-dentistry/protein-ire1
Protein IRE1 - an overview | ScienceDirect Topics

A Futile Battle? Protein Quality Control and the Stress of Aging

A Futile Battle? Protein Quality Control and the Stress of Aging - ScienceDirect

Structure and Molecular Mechanism of ER Stress Signaling by the Unfolded...

Frontiers | Structure and Molecular Mechanism of ER Stress Signaling by the Unfolded Protein Response Signal Activator IRE1 | Molecular Biosciences

fmolb-06-00011-g001.jpg (JPEG Image, 762 × 693 pixels)

PERK-Mediated Unfolded Protein Response Activation and Oxidative Stress in...

Frontiers | PERK-Mediated Unfolded Protein Response Activation and Oxidative Stress in PARK20 Fibroblasts | Neuroscience

Feedbacks, Bifurcations, and Cell Fate Decision-Making in the p53 System

Feedbacks, Bifurcations, and Cell Fate Decision-Making in the p53 System | PLOS Computational Biology

Life and Death Decision-Making by p53 and Implications for Cancer Immunotherapy

Life and Death Decision-Making by p53 and Implications for Cancer Immunotherapy - ScienceDirect
https://www.pnas.org/doi/10.1073/pnas.0813088106
Cell fate decision mediated by p53 pulses | PNAS
https://www.google.com/search?client=firefox-b-1-d&q=p53AIP1
p53AIP1 - Google Search

p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation...

p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53 - PubMed
https://www.cell.com/trends/cancer/fulltext/S2405-8033(20)30279-X
Life and Death Decision-Making by p53 and Implications for Cancer Immunotherapy: Trends in Cancer

Decision Making by p53: Life versus Death

Decision Making by p53: Life versus Death - PMC
https://www.google.com/search?client=firefox-b-1-d&q=nuclear+export+signals
nuclear export signals - Google Search
https://www.google.com/search?client=firefox-b-1-d&q=nuclear+localization+signal
nuclear localization signal - Google Search

The guardian's choice: how p53 enables context-specific decision-making in...

The guardian’s choice: how p53 enables context-specific decision-making in individual cells - PubMed
https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.15767
The guardian’s choice: how p53 enables context‐specific decision‐making in individual cells - Friedel - 2022 - The FEBS Journal - Wiley Online Library
https://www.nature.com/articles/s41586-018-0162-7
Disruption of the beclin 1–BCL2 autophagy regulatory complex promotes longevity in mice | Nature

Role of the Crosstalk between Autophagy and Apoptosis in Cancer

Role of the Crosstalk between Autophagy and Apoptosis in Cancer
https://www.google.com/search?client=firefox-b-1-d&q=dram+puma+apoptosis+autophagy
dram puma apoptosis autophagy - Google Search

The p53 Upregulated Modulator of Apoptosis (PUMA) Chemosensitizes...

The p53 Upregulated Modulator of Apoptosis (PUMA) Chemosensitizes Intrinsically Resistant Ovarian Cancer Cells to Cisplatin by Lowering the Threshold Set by Bcl-xL and Mcl-1 - PMC
https://www.google.com/search?client=firefox-b-1-d&q=p300+histones
p300 histones - Google Search

p53 Acetylation: Regulation and Consequences

p53 Acetylation: Regulation and Consequences - PMC

Acetylation of the p53 DNA binding domain regulates apoptosis induction.

Acetylation of the p53 DNA binding domain regulates apoptosis induction. - PMC

Regulation of Histone Acetyltransferase TIP60 Function by Histone Deacetylase 3

Regulation of Histone Acetyltransferase TIP60 Function by Histone Deacetylase 3 - PMC
https://www.nature.com/articles/1210608
The MYST family of histone acetyltransferases and their intimate links to cancer | Oncogene
https://onlinelibrary.wiley.com/doi/10.1002/bies.200900051
MYST family histone acetyltransferases take center stage in stem cells and development - Voss - 2009 - BioEssays - Wiley Online Library

p53 modifications: exquisite decorations of the powerful guardian

p53 modifications: exquisite decorations of the powerful guardian | Journal of Molecular Cell Biology | Oxford Academic

p53 modifications: exquisite decorations of the powerful guardian

p53 modifications: exquisite decorations of the powerful guardian | Journal of Molecular Cell Biology | Oxford Academic
https://www.google.com/search?client=firefox-b-1-d&q=proteasome+post+translational+modifications
proteasome post translational modifications - Google Search

Regulation of Proteasome Activity by (Post-)transcriptional Mechanisms

Frontiers | Regulation of Proteasome Activity by (Post-)transcriptional Mechanisms | Molecular Biosciences

Post-Translational Modifications of Extracellular Proteasome

Post-Translational Modifications of Extracellular Proteasome - PMC

Regulation of Proteasome Activity by (Post-)transcriptional Mechanisms

Regulation of Proteasome Activity by (Post-)transcriptional Mechanisms - PMC
http://incountryvalueoman.net/homes.aspx?iid=24517758&cid=21
Service Unavailable
https://www.researchgate.net/figure/Proposed-model-for-PUMA-mediated-apoptosis-PUMA-P53-upregulated-modulator-of-apoptosis_fig3_350498098
Proposed model for PUMA-mediated apoptosis. PUMA (P53 upregulated… | Download Scientific Diagram
https://www.google.com/search?client=firefox-b-1-d&q=dna+binding+domain+of+p53
dna binding domain of p53 - Google Search

fimmu-11-00484-g001.jpg (JPEG Image, 957 × 604 pixels)
https://www.hindawi.com/journals/jo/2013/102735/fig1/
Figure 1 | Role of the Crosstalk between Autophagy and Apoptosis in Cancer

Dying to Survive-The p53 Paradox - PubMed

Dying to Survive-The p53 Paradox - PubMed

The Roles of Histone Deacetylases and Their Inhibitors in Cancer Therapy

Frontiers | The Roles of Histone Deacetylases and Their Inhibitors in Cancer Therapy | Cell and Developmental Biology
https://www.google.com/search?q=p53+domains&client=firefox-b-1-d&sxsrf=ALiCzsabxDo5OGAY4X8D5QlRnEAtI09i9w%3A1652688216540&ei=WAWCYs3TIOOJptQP6rejyAc&ved=0ahUKEwjN38iwx-P3AhXjhIkEHerbCHkQ4dUDCA0&uact=5&oq=p53+domains&gs_lcp=Cgdnd3Mtd2l6EAMyBAgjECcyBQgAEIAEMgYIABAWEB4yBggAEBYQHjIGCAAQFhAeMggIABAPEBYQHjIKCAAQDxAWEAoQHjIICAAQDxAWEB4yCAgAEA8QFhAeMgUIABCGAzoECAAQQzoFCAAQkQI6BwgAELEDEEM6DQgAEIAEEIcCELEDEBQ6CAgAEIAEELEDOgoIABCABBCHAhAUSgQIQRgBSgQIRhgAUP0iWNEqYPAraARwAHgAgAGiAYgBpQiSAQM4LjOYAQCgAQHAAQE&sclient=gws-wiz
p53 domains - Google Search

Nutlin-3a: A Potential Therapeutic Opportunity for TP53 Wild-Type Ovarian...

Nutlin-3a: A Potential Therapeutic Opportunity for TP53 Wild-Type Ovarian Carcinomas - PubMed

PUMA, a potent killer with or without p53

PUMA, a potent killer with or without p53 - PMC

PUMA, a potent killer with or without p53

PUMA, a potent killer with or without p53 - PMC

[AlexKChen]

https://www.cell.com/fulltext/S0092-8674(11)01007-5
Beclin1 Controls the Levels of p53 by Regulating the Deubiquitination Activity of USP10 and USP13: Cell

The most promising supplements/small molecules for longevity

lyosomal acidifiers (only in old ppl) - https://pubs.acs.org/doi/10.1021/acschemneuro.1c00804 valproic acid in c elegans? Valproic acid - is it pro-longevity or anti-longevity? (it helps open up chromatin, which might make it more damage-prone) - Rapamycin News bromodomain inhibitors? => i would not expect huge effect sizes in these, but some of these can be targeted well…

The most promising supplements/small molecules for longevity - akc-important-threads - LongevityBase Forum

Beclin 1, an autophagy-related gene, augments apoptosis in U87 glioblastoma...

Beclin 1, an autophagy-related gene, augments apoptosis in U87 glioblastoma cells

Progress and challenges in understanding the regulation and function of p53...

Progress and challenges in understanding the regulation and function of p53 dynamics | Biochemical Society Transactions | Portland Press
https://aip.scitation.org/doi/10.1063/5.0030558
Landscape and flux quantify the stochastic transition dynamics for p53 cell fate decision: The Journal of Chemical Physics: Vol 154, No 2
https://www.nature.com/articles/cdd201526
DRAM-3 modulates autophagy and promotes cell survival in the absence of glucose | Cell Death & Differentiation

DRAM links autophagy to p53 and programmed cell death - PubMed

DRAM links autophagy to p53 and programmed cell death - PubMed
https://www.cell.com/fulltext/S0092-8674(06)00759-8
DRAM, a p53-Induced Modulator of Autophagy, Is Critical for Apoptosis: Cell

PUMA, a potent killer with or without p53

PUMA, a potent killer with or without p53 - PMC
https://www.google.com/search?q=transcription+factors+CHOP&client=firefox-b-1-d&sxsrf=ALiCzsa1L-XuAoOmzFjSN8y9gbuSxLVDVw:1652683578832&tbm=isch&source=iu&ictx=1&vet=1&fir=aCeQWDhBZGSlWM%2CPFc-tdpFOCzhiM%2C_%3Blf-MXT8UZxVAoM%2CPFc-tdpFOCzhiM%2C_&usg=AI4_-kSsYGJYGQhGG-PUZ0YVG3bSIyt11w&sa=X&ved=2ahUKEwitu5GNtuP3AhWglIkEHbQHBuAQ_h16BAgsEAE&biw=1352&bih=1079&dpr=0.9#imgrc=B8oH_RREDWAYEM
transcription factors CHOP - Google Search

The C/EBP Homologous Protein (CHOP) Transcription Factor Functions in...

Frontiers | The C/EBP Homologous Protein (CHOP) Transcription Factor Functions in Endoplasmic Reticulum Stress-Induced Apoptosis and Microbial Infection | Immunology

fimmu-09-03083-g001.jpg (JPEG Image, 772 × 479 pixels)

ERN1

ERN1 - Wikipedia
https://www.sciencedirect.com/topics/medicine-and-dentistry/protein-ire1
Protein IRE1 - an overview | ScienceDirect Topics

A Futile Battle? Protein Quality Control and the Stress of Aging

A Futile Battle? Protein Quality Control and the Stress of Aging - ScienceDirect

Structure and Molecular Mechanism of ER Stress Signaling by the Unfolded...

Frontiers | Structure and Molecular Mechanism of ER Stress Signaling by the Unfolded Protein Response Signal Activator IRE1 | Molecular Biosciences

fmolb-06-00011-g001.jpg (JPEG Image, 762 × 693 pixels)

PERK-Mediated Unfolded Protein Response Activation and Oxidative Stress in...

Frontiers | PERK-Mediated Unfolded Protein Response Activation and Oxidative Stress in PARK20 Fibroblasts | Neuroscience

Feedbacks, Bifurcations, and Cell Fate Decision-Making in the p53 System

Feedbacks, Bifurcations, and Cell Fate Decision-Making in the p53 System | PLOS Computational Biology

Life and Death Decision-Making by p53 and Implications for Cancer Immunotherapy

Life and Death Decision-Making by p53 and Implications for Cancer Immunotherapy - ScienceDirect
https://www.pnas.org/doi/10.1073/pnas.0813088106
Cell fate decision mediated by p53 pulses | PNAS
https://www.google.com/search?client=firefox-b-1-d&q=p53AIP1
p53AIP1 - Google Search

p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation...

p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53 - PubMed
https://www.cell.com/trends/cancer/fulltext/S2405-8033(20)30279-X
Life and Death Decision-Making by p53 and Implications for Cancer Immunotherapy: Trends in Cancer

Decision Making by p53: Life versus Death

Decision Making by p53: Life versus Death - PMC
https://www.google.com/search?client=firefox-b-1-d&q=nuclear+export+signals
nuclear export signals - Google Search
https://www.google.com/search?client=firefox-b-1-d&q=nuclear+localization+signal
nuclear localization signal - Google Search

The guardian's choice: how p53 enables context-specific decision-making in...

The guardian’s choice: how p53 enables context-specific decision-making in individual cells - PubMed
https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.15767
The guardian’s choice: how p53 enables context‐specific decision‐making in individual cells - Friedel - 2022 - The FEBS Journal - Wiley Online Library
https://www.nature.com/articles/s41586-018-0162-7
Disruption of the beclin 1–BCL2 autophagy regulatory complex promotes longevity in mice | Nature

Role of the Crosstalk between Autophagy and Apoptosis in Cancer

Role of the Crosstalk between Autophagy and Apoptosis in Cancer
https://www.google.com/search?client=firefox-b-1-d&q=dram+puma+apoptosis+autophagy
dram puma apoptosis autophagy - Google Search

The p53 Upregulated Modulator of Apoptosis (PUMA) Chemosensitizes...

The p53 Upregulated Modulator of Apoptosis (PUMA) Chemosensitizes Intrinsically Resistant Ovarian Cancer Cells to Cisplatin by Lowering the Threshold Set by Bcl-xL and Mcl-1 - PMC
https://www.google.com/search?client=firefox-b-1-d&q=p300+histones
p300 histones - Google Search

p53 Acetylation: Regulation and Consequences

p53 Acetylation: Regulation and Consequences - PMC

Acetylation of the p53 DNA binding domain regulates apoptosis induction.

Acetylation of the p53 DNA binding domain regulates apoptosis induction. - PMC

Regulation of Histone Acetyltransferase TIP60 Function by Histone Deacetylase 3

Regulation of Histone Acetyltransferase TIP60 Function by Histone Deacetylase 3 - PMC
https://www.nature.com/articles/1210608
The MYST family of histone acetyltransferases and their intimate links to cancer | Oncogene
https://onlinelibrary.wiley.com/doi/10.1002/bies.200900051
MYST family histone acetyltransferases take center stage in stem cells and development - Voss - 2009 - BioEssays - Wiley Online Library

p53 modifications: exquisite decorations of the powerful guardian

p53 modifications: exquisite decorations of the powerful guardian | Journal of Molecular Cell Biology | Oxford Academic

p53 modifications: exquisite decorations of the powerful guardian

p53 modifications: exquisite decorations of the powerful guardian | Journal of Molecular Cell Biology | Oxford Academic
https://www.google.com/search?client=firefox-b-1-d&q=proteasome+post+translational+modifications
proteasome post translational modifications - Google Search

Regulation of Proteasome Activity by (Post-)transcriptional Mechanisms

Frontiers | Regulation of Proteasome Activity by (Post-)transcriptional Mechanisms | Molecular Biosciences

Post-Translational Modifications of Extracellular Proteasome

Post-Translational Modifications of Extracellular Proteasome - PMC

Regulation of Proteasome Activity by (Post-)transcriptional Mechanisms

Regulation of Proteasome Activity by (Post-)transcriptional Mechanisms - PMC
http://incountryvalueoman.net/homes.aspx?iid=24517758&cid=21
Service Unavailable
https://www.researchgate.net/figure/Proposed-model-for-PUMA-mediated-apoptosis-PUMA-P53-upregulated-modulator-of-apoptosis_fig3_350498098
Proposed model for PUMA-mediated apoptosis. PUMA (P53 upregulated… | Download Scientific Diagram
https://www.google.com/search?client=firefox-b-1-d&q=dna+binding+domain+of+p53
dna binding domain of p53 - Google Search

fimmu-11-00484-g001.jpg (JPEG Image, 957 × 604 pixels)
https://www.hindawi.com/journals/jo/2013/102735/fig1/
Figure 1 | Role of the Crosstalk between Autophagy and Apoptosis in Cancer

Dying to Survive-The p53 Paradox - PubMed

Dying to Survive-The p53 Paradox - PubMed

The Roles of Histone Deacetylases and Their Inhibitors in Cancer Therapy

Frontiers | The Roles of Histone Deacetylases and Their Inhibitors in Cancer Therapy | Cell and Developmental Biology
https://www.google.com/search?q=p53+domains&client=firefox-b-1-d&sxsrf=ALiCzsabxDo5OGAY4X8D5QlRnEAtI09i9w%3A1652688216540&ei=WAWCYs3TIOOJptQP6rejyAc&ved=0ahUKEwjN38iwx-P3AhXjhIkEHerbCHkQ4dUDCA0&uact=5&oq=p53+domains&gs_lcp=Cgdnd3Mtd2l6EAMyBAgjECcyBQgAEIAEMgYIABAWEB4yBggAEBYQHjIGCAAQFhAeMggIABAPEBYQHjIKCAAQDxAWEAoQHjIICAAQDxAWEB4yCAgAEA8QFhAeMgUIABCGAzoECAAQQzoFCAAQkQI6BwgAELEDEEM6DQgAEIAEEIcCELEDEBQ6CAgAEIAEELEDOgoIABCABBCHAhAUSgQIQRgBSgQIRhgAUP0iWNEqYPAraARwAHgAgAGiAYgBpQiSAQM4LjOYAQCgAQHAAQE&sclient=gws-wiz
p53 domains - Google Search

Nutlin-3a: A Potential Therapeutic Opportunity for TP53 Wild-Type Ovarian...

Nutlin-3a: A Potential Therapeutic Opportunity for TP53 Wild-Type Ovarian Carcinomas - PubMed

PUMA, a potent killer with or without p53

PUMA, a potent killer with or without p53 - PMC

PUMA, a potent killer with or without p53

PUMA, a potent killer with or without p53 - PMC

[AlexKChen]

G-protein hetereodimzeration

FGF21 as Modulator of Metabolism in Health and Disease

Frontiers | FGF21 as Modulator of Metabolism in Health and Disease | Physiology

FGF21 as Modulator of Metabolism in Health and Disease

Frontiers | FGF21 as Modulator of Metabolism in Health and Disease | Physiology
https://www.google.com/search?q=growth+hormone+mtorc2&client=firefox-b-1-d&sxsrf=ALiCzsZpkbouEG7x1zjxRye_HTrbBeqqxw%3A1652660633606&ei=mZmBYoHhJLmgptQP9aizgAc&ved=0ahUKEwjBkYDQ4OL3AhU5kIkEHXXUDHAQ4dUDCA0&uact=5&oq=growth+hormone+mtorc2&gs_lcp=Cgdnd3Mtd2l6EAMyBQgAEKIEOgcIABBHELADOgQIIxAnOgUIABCRAjoHCAAQsQMQQzoLCAAQgAQQsQMQgwE6EQguEIAEELEDEIMBEMcBENEDOggIABCABBCxAzoOCC4QgAQQsQMQxwEQ0QM6EQguEIAEELEDEIMBEMcBEKMCOggILhCxAxCDAToICAAQsQMQgwE6CAgAEIAEEMkDOgUIABCSAzoFCC4QgAQ6CwguEIAEELEDEIMBOgUIABCABDoICC4QgAQQsQM6BggAEBYQHjoFCAAQhgM6BAgAEA1KBAhBGABKBAhGGABQxQhYuhlgpxxoA3ABeACAAZQBiAHoEJIBBDEyLjmYAQCgAQHIAQjAAQE&sclient=gws-wiz
growth hormone mtorc2 - Google Search

Rapamycin-mediated mTORC2 inhibition is determined by the relative expression...

Rapamycin-mediated mTORC2 inhibition is determined by the relative expression of FK506-binding proteins - PMC

mTOR Signaling in Growth, Metabolism, and Disease

mTOR Signaling in Growth, Metabolism, and Disease - ScienceDirect

Phosphatidylinositol (3,4,5)-trisphosphate

Phosphatidylinositol (3,4,5)-trisphosphate - Wikipedia

Transcriptomics-based screening identifies pharmacological inhibition of...

Transcriptomics-based screening identifies pharmacological inhibition of Hsp90 as a means to defer aging | bioRxiv

FGF21 is an Akt-regulated myokine

FGF21 is an Akt-regulated myokine - PMC
https://www.google.com/search?q=LY294002+mouse+longevity&client=firefox-b-1-d&sxsrf=ALiCzsYUWWKt-_trWKsX9j65B2s1OCuSAg%3A1652658019663&ei=Y4-BYpuTKJWbptQP7MKT-A4&ved=0ahUKEwjb0Mnx1uL3AhWVjYkEHWzhBO8Q4dUDCA0&uact=5&oq=LY294002+mouse+longevity&gs_lcp=Cgdnd3Mtd2l6EAM6BAgAEEc6BQghEKsCSgQIQRgASgQIRhgAUNIRWKksYLstaAJwAngAgAFaiAHqCZIBAjE4mAEAoAEByAEIwAEB&sclient=gws-wiz
LY294002 mouse longevity - Google Search

MAPKpathway - MAPK/ERK pathway - Wikipedia

The Mitogen-Activated Protein Kinase (MAPK) Pathway: Role in Immune Evasion...

Frontiers | The Mitogen-Activated Protein Kinase (MAPK) Pathway: Role in Immune Evasion by Trypanosomatids | Microbiology
https://www.google.com/search?q=igf1r+pathway&client=firefox-b-1-d&sxsrf=ALiCzsaVIbsEN-cCDnxxuJQh6CMU02Kx9A:1652661874981&source=lnms&tbm=isch&sa=X&ved=2ahUKEwjQxvef5eL3AhUXmIkEHbDSCz0Q_AUoAXoECAEQAw&biw=1200&bih=1079&dpr=0.9
igf1r pathway - Google Search

Molecular Pathways: Clinical Applications and Future Direction of...

Molecular Pathways: Clinical Applications and Future Direction of Insulin-Like Growth Factor-1 Receptor Pathway Blockade - PMC

Niche Modulation of IGF-1R Signaling: Its Role in Stem Cell Pluripotency,...

Frontiers | Niche Modulation of IGF-1R Signaling: Its Role in Stem Cell Pluripotency, Cancer Reprogramming, and Therapeutic Applications | Cell and Developmental Biology

Glutamate receptor | Glutamate receptors

Glutamate receptor - Wikipedia

Phosphoinositide 3-kinase

Phosphoinositide 3-kinase - Wikipedia
https://www.google.com/search?client=firefox-b-1-d&q=arc+institute
arc institute - Google Search

Metabotropic glutamate receptor 2

Metabotropic glutamate receptor 2 - Wikipedia

Gi alpha subunit

Gi alpha subunit - Wikipedia

Heterotrimeric G protein

Heterotrimeric G protein - Wikipedia
https://docs.google.com/document/d/1EtZ1aI193rdaxxySe7-9ArfzfXmensjsP9SZRoN3gA8/edit
Untitled document - Google Docs

CHRNA7

CHRNA7 - Wikipedia

Protein subunit

Protein subunit - Wikipedia

Dopamine receptor D2

Dopamine receptor D2 - Wikipedia

GNA11

GNA11 - Wikipedia

GNA14

GNA14 - Wikipedia

G beta-gamma complex

G beta-gamma complex - Wikipedia

Defining the Homo- and Heterodimerization Propensities of Metabotropic...

Defining the Homo- and Heterodimerization Propensities of Metabotropic Glutamate Receptors - PubMed

Defining the Homo- and Heterodimerization Propensities of Metabotropic...

Defining the Homo- and Heterodimerization Propensities of Metabotropic Glutamate Receptors - PMC

fgene-05-00181-g001.jpg (JPEG Image, 2000 × 456 pixels) — Scaled (55%)

Src family kinases, adaptor proteins and the actin cytoskeleton in...

Src family kinases, adaptor proteins and the actin cytoskeleton in epithelial-to-mesenchymal transition | Cell Communication and Signaling | Full Text

Janus kinase

Signal transduction pathways - Janus kinase - Wikipedia

Activation of the IGF1R pathway potentially mediates acquired resistance to...

Activation of the IGF1R pathway potentially mediates acquired resistance to mutant-selective 3rd-generation EGF receptor tyrosine kinase inhibitors in advanced non-small cell lung cancer - PubMed
https://www.pnas.org/doi/10.1073/pnas.2019474118
Distinct signaling by insulin and IGF-1 receptors and their extra- and intracellular domains | PNAS

Canonical aging papers (more worth reading than others)

Canonical aging papers (more worth reading than others) - akc-important-threads - LongevityBase Forum

Phosphatidylinositol 4,5-bisphosphate

Phosphatidylinositol 4,5-bisphosphate - Wikipedia

Review of PIP2 in Cellular Signaling, Functions and Diseases

Review of PIP2 in Cellular Signaling, Functions and Diseases - PMC

Inorganic Phosphate Activates the AKT/mTORC1 Pathway and Shortens the Life...

Inorganic Phosphate Activates the AKT/mTORC1 Pathway and Shortens the Life Span of an α‑Klotho–Deficient Model | American Society of Nephrology

Cancer inhibition by inositol hexaphosphate (IP6) and inositol

Cancer inhibition by inositol hexaphosphate (IP6) and inositol - Rapamycin Longevity News

Microtubules Regulate Migratory Polarity through Rho/ROCK Signaling in T Cells

Microtubules Regulate Migratory Polarity through Rho/ROCK Signaling in T Cells | PLOS ONE
https://www.nature.com/articles/cddis201310
Distinct roles for ROCK1 and ROCK2 in the regulation of cell detachment | Cell Death & Disease

Is methylene blue useful?

Is methylene blue useful? - Rapamycin Longevity News
https://www.nature.com/articles/ncomms13683
Fatty acid metabolic reprogramming via mTOR-mediated inductions of PPARγ directs early activation of T cells | Nature Communications

FGF21 as Modulator of Metabolism in Health and Disease

Frontiers | FGF21 as Modulator of Metabolism in Health and Disease | Physiology

Rapamycin Does Not Interact Favorably with Growth Hormone Receptor Knockout

Rapamycin Does Not Interact Favorably with Growth Hormone Receptor Knockout – Fight Aging!
https://www.pnas.org/doi/10.1073/pnas.1717065115
Effects of rapamycin on growth hormone receptor knockout mice | PNAS

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G beta-gamma complex - Wikipedia

List of U.S. states and territories by GDP

List of U.S. states and territories by GDP - Wikipedia