Protein synthesis is not equally accurate across organs. Excited to share our new preprint: https://biorxiv.org/content/10.64898/2026.04.01.715671v1 We developed a new mouse model to quantitatively monitor translation errors and uncovered the spatiotemporal dynamics of the “quality” of protein synthesis.
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Surprisingly, early embryos exhibit high error rates. As development proceeds, organ-specific fidelity programs emerge. In adults, the brain shows the lowest error rate, which was also observed in Ribo-seq.
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These findings demonstrate that translation fidelity is not a fixed constant, but a dynamic parameter that changes across development, differentiation, and aging. Congrats to Jacob Best, Dr. Indu Tripathi, and Sunfeel Akaphan for leading this work and making these observations.