My total list of longevity questions (that I won't post as separate threads to clog up the forum - answer them if you have any!)

#1

Do super-long lived organisms have more cysteine/methionine in their genomes as sites to soak up extra free radical damage (so they don’t hit more active sites in the protein)?
Don’t cell-cycle genes also decrease in calorie restricted/IGF1 deficient individuals?
Do we have dN/dS values for NMR longevity genes and are they higher for genes in long-lived bowhead whales?

https://www.quora.com/What-does-your-Your-Content-page-for-the-biochemistry-topic-look-like?q=your%20content%20biochemistry

https://www.quora.com/unanswered/What-does-your-Your-Content-page-for-the-neuroscience-topic-look-like

#2

Additionally, we identified a linear DNAm signature, indicative
of a global demethylation level. Through single-cell DNAm (scDNAm) data from aging animals,
we demonstrate that this signature captures the exponential expansion of the state space volume
spanned by individual cells within an aging organism, and thus quantifying linearly increasing configuration entropy, likely an irreversible process

Why demethylation level only? Wasn’t Andrei Tarkov’s paper on both levels?