Free-roaming Fats, Oxidative Stress, Inflammation, and the Effects of AGEs
Several common symptoms of metabolic disorders, which often exacerbate each other, could also accelerate cognitive decline.
Dyslipidemia is an imbalance in the various fats found roaming in the blood. Triglycerides become particularly elevated in metabolic syndrome and have been associated with cognitive impairment. In mice, these fats crossed the blood-brain barrier and triggered leptin and insulin resistance, which increased appetite and reduced cognition. Lowering their blood triglycerides reversed these effects, presenting a potential path to alleviate cognitive impairment and improve weight loss in people with obesity.
well fuck, I had elevated TGs after a panel. I eat SO many MUFAs that I wonder if it’s a concern…
Similarly, cholesterol ratios like triglycerides-to-HDL have been shown to potentially be a better gauge of health risk than LDL cholesterol levels alone
- Your ratio of triglycerides
to HDL should be no greater than 4, which can indicate insulin resistance if elevated