Molecules | Free Full-Text | Melatonin: Regulation of Prion Protein Phase Separation in Cancer Multidrug Resistance | HTML (THE IDEAL REVIEW PAPER)
manolis kellis youtube
SCIENTIFIC PROGRESS OUTSIDE OF AGING
https://erikhoel.substack.com/ (NOT LONGEVITY, BUT READ ANYWAYS)
https://medium.com/1517/a-new-95-ec071200d98f
https://noahweber1.github.io/Computational_Longevity/Chapter%201%20-%20Motivation.html
nxn.se AND jacob kimmel AND Jean Fan on RNA-seq
iBiology on proteasomes (3-series) is SO amazing and clear. Deshaies (Amgen) 1: A primer on the ubiquitin-proteasome system - YouTube
A Futile Battle? Protein Quality Control and the Stress of Aging (DILLIN)
cryostasis revival - fahy
Quantum Reports | Free Full-Text | Quantum Biology: An Update and Perspective | HTML (wouldn’t call it CENTRAL but some chance of being super-interesting)
Ways to accelerate aging research – Longitudinal Science (MORE THAN ANYTHING ELSE)
In their study, published in Nature, titled, “Undulating Changes in Human Plasma Proteome Profiles Across the Lifespan,” the scientists stated that aging doesn’t happen in a consistent process over time, reported Science Alert.
https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.14818 (my fav ECM paper so far)
https://www.nature.com/articles/s41588-022-01279-6 (transcriptional stalling of RNA polymerase II) - a basis for the DNA damage theory of aging
Bioengineering | Free Full-Text | An In Vivo Platform for Rebuilding Functional Neocortical Tissue (jean hebert presented at zuzalu). hard to understand due to overly idiosyncratic terms tho
The latest review on ECM by Ewald, King, English…
We built a “#Strategic outline of #interventions targeting #extracellular #matrix for promoting #healthy #longevity” #technologytree. 22’459 words & 557 references by @CeciliaPark, Aaron King, Victor Björk Brad English
Aleksandr Fedintsev @AJPCellPhys
https://lnkd.in/eF8QuwMu
What determines protein levels ?
For many proteins, abundance variation is dominated by clearance (degradation & dilution) variation. 
Globally, clearance variation across tissues (e.g., brain & pancreas) explains ~ 40 % of protein abundance variation.
To determine the dominant regulatory mechanisms, we quantified the degree of compensation between activated and resting human B cells and across mouse tissues. The results indicate that growth-dependent dilution is insufficiently compensated for by changes in protein synthesis, and it accounts for over a third of the concentration changes between high and low growth conditions. Furthermore, we find that about 25 % of the differences in protein concentration across all tissues are controlled by protein clearance. When comparing only slowly growing tissues such as the brain and pancreas, clearance differences explain as much as 42 %. Within a tissue or cell type, clearance variation is sufficient to account for 50 % of the abundance variation for all measured proteins at slow growth, contrasted with 7 % at fast growth. Thus, our model unifies previous observations with our new results and highlights a context-dependent and larger than previously appreciated contribution of protein degradation in shaping protein variation both across the proteome and across cell states.