https://onlinelibrary.wiley.com/doi/10.1111/acel.14056
E2F1, HDAC1 go down with age, associated with Steiner S3. But their interchromosome connections are non-obvious
Chromosome changes are fastest in the very old
CEBPB and REEPB5 were marked as significant…
resulting intermingling difference map among all loci is shown in Figure 3c. Interestingly, almost all intrachromosomal LAS submatrices were shared among young and old fibroblasts (Figure 3d(i), overlap of 99.995%), while 15.5% of the interchromosomal intermingling regions were specific to either the old cell state or the young cell state (Figure 3d(ii)). The rearrangements between the young and old states at the chromosome level are shown in Figure S14D and examples of difference maps are provided for chromosome 17 in cis (Figure S11A) and for the chromosome pair 17-19 in trans (Figure 3e and Figure S11B). In the latter, one LAS submatrix was present only in the young condition (colored in blue) and one submatrix only in the old condition (colored in magenta). These results suggest that the intrachromosomal chromatin organization is rather stable during aging, and the chromatin reorganization is mostly happening via changes in interchromosomal contacts. Although interchromosomal interactions have been less studied in the past compared to intrachromosomal chromatin interactions, there has been increasing evidence supporting their role in cell type-/state-specific gene regulation (Maass et al., 2019).