How to reduce brain decline with age (or maximize mindspan)

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Some studies reported large positive associations between accelerated epigenetic age and poorer
structural brain integrity (Davis et al., 2017; Hillary et al., 2021; Proskovec et al., 2020), while others
reported small positive associations (Milicic et al., 2022; Raina et al., 2017), and still others reported null
> associations or even associations in the opposite direction (Cheong et al., 2022; Chouliaras et al., 2018).

^this is only of 1st-gen epigenetic clocks

Klotho gene therapy

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(NOTE: this focuses more on the macrostructure (eg synapses) than the microstructure (eg mitochondrial/nuclear integrity)

https://twitter.com/MasudHusain/status/1781987710300807548?t=ogUDFc6s1qS12kAEN7S-rA&s=19